Hereditary spastic paraplegia
GENETICALLY AND CLINICALLY HETEROGENEOUS GROUP OF NEURODEGENERATIVE DISORDERS CHARACTERIZED BY PROGRESSIVE SPASTICITY AND HYPERREFLEXIA OF THE LOWER LIMBS
Familial spastic paraparesis; Strumpell-lorrain disease; Spastic ataxia; Spastic paraplegia, hereditary; Spastic paraplegia; Strümpell-Lorrain disease; Strumpell-Lorrain disease; Struempell-Lorrain disease; Hereditary Spastic Paraplegia; Spastic paraplegia type 1, X-linked; Spastic paraplegia type 2, X-linked; Spastic paraplegia type 3, dominant; Spastic paraplegia type 4, dominant; Spastic paraplegia type 6, dominant; Spastic paraplegia, familial; Silver syndrome; Strumpell disease; Lison syndrome; Troyer syndrome; Kjellin syndrome; Spastic paraplegia type 5A, recessive; Spastic paraplegia type 5B, recessive; Familial spastic paraplegia; Familial spastic paralysis; Strumpell–Lorrain disease; SPG5B; SPG5B (gene)
Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder. The disease presents with progressive stiffness (spasticity) and contraction in the lower limbs.